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Brain cells are vulnerable to oxidative stress, which damages DNA and proteins and could contribute to cognitive decline and dementia
Given that GHK-Cu is a naturally occurring molecule present in human plasma, concerns about long-term topical use seem largely theoretical
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Gumeni S, Papanagnou ED, Manola MS, Trougakos IP

The increase in MDHAR activity has been reported in stress conditions like salinity, high light, UV radiation, boron toxicity and low temperature (Mittova et al., 2003
