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The pathogenesis of CIPN is multifactorial, involving oxidative stress, neuroinflammation, neurotrophic factor depletion, and mitochondrial dysfunction (610)

10.3109/09637480903286363 136 ZhangD.LiptonS

While CpG dinucleotide methylation remains stable in many contexts, other forms of methylation, such as CH methylation, play crucial roles during early brain development (Ma et al., 2017)

Vitamins are important for keeping nerves healthy and easing symptoms

Unsurpassed in its ability to bind to and remove lead, vitamin C is highly effective at alleviating lead toxicity [55]

Altogether, the interplay between glutamatergic hyperactivity and GABAergic insufficiency underpins seizure initiation and propagation