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Since these alterations provide the basis for cancer, 2HG is described as oncometabolite

These metabolites regulate intestinal barrier integrity, energy metabolism, and ovarian function by activating the AhR, modulating immune responses (e.g., IL-22), and influencing neuroendocrine pathways (e.g., 5-HT signaling (8587)

doi: 10.1152/ajpgi.1989.256.1.G22

Fluids Barriers CNS 2020, 17 (1), 69, DOI: 10.1186/s12987-020-00230-3Google Scholar13A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrityKadry Hossam

Studies have demonstrated that innovative formulations of GA, including nanoparticles, gels, colloids, nanoemulsions, and liposomes, significantly enhance its bioavailability, solubility, and transmembrane transport

In some embodiments, the formulation or composition comprises between about 0.01% to about 15% by weight of the viscosity modulating agent