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In addition, interactions between T cells and macrophages can influence macrophage activation and may be associated with changes in iNOS expression and inflammatory responses in the vascular wall, thereby contributing to the immunopathogenesis of vasculitis (103)

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Disparities in care In developing economies, median native kidney survival is 6.4 years shorter than in developed economies [159]

Most of the anti-inflammatory effects of PPARs result from their inhibition of the NF-B signaling pathway, which also inhibits the production of various genes implicated in the inflammatory response, including iNOS, IL-6, and IL-12 58