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IENF loss without degeneration of peripheral nerve axons and associated with mitochondrial dysfunction Unmyelinated fibers and terminal nerve arbors are major sites of cancer chemotherapy-induced neurotoxicity (Grisold et al., 2012) such that intraepidermal nerve fiber (IENF) loss or terminal arbor degeneration is proposed as a common lesion in various toxic neuropathies (Bennett et al., 2011

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There were also noted improvements in markers of glycemic control and insulin sensitivity