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Matrone, C., Iannuzzi, F

Study Details Source Related Guidelines: Pharmacological Management of United States Adults with Overweight or Obesity The Obesity Society (TOS), Obesity Medicine Association (OMA), Obesity Action Coalition (OAC), March 2026 Management of Adult Overweight and Obesity Veterans Health Administration / Department of Defense (VA/DOD), November 2025 Sign up for alerts and stay informed on the latest published guidelines.

86 Curcumin Curcumin, a polyphenol derived from turmeric ( Curcuma longa ), modulates cytochrome p450 enzymes, particularly CYP1A1, CYP1A2, and CPY3A4, and increases the activity of GSTs and quinone reductase (QR)

More interestingly, the treatment of mice with the GluN2B antagonist ifenprodil (2.5 mg/kg body weight) prevented the growth of PanC-1 tumor xenografts and decreased the tumor size by almost half, indicating that ifenprodil is more effective in the inhibition of NMDAR in vivo (107)

doi: 10.1158/1055-9965.EPI-20-0743 118 SouleSKingJAMillarRP

Table 1 Key metabolic pathways, targets, and metabolite alterations involved in RA pathogenesis
