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Retinopathy evaluation was performed at least annually by ophthalmologists

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The brain-derived neurotrophic factor (BDNF) and its receptor, tyrosine kinase receptor B (TrkB), are essential and common mechanisms for the antidepressant effects of both the parent molecules of ketamines [i.e., S, R()ketamine, S(+)ketamine, and R()ketamine] and their active metabolites [i.e., (2R,6R)-hydroxynorketamine and of S(+)norketamine] (Yang et al., 2019)

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The experimental protocol was approved by the Animal Care Committee of AMU in accordance with the governments guidelines for animal manipulations in China