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[Google Scholar] Zhang X, Cui Y, Dong L, Sun M, Zhang Y.2020
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The implementation of aerobic endurance training results in an elevation of shear stress and a chronic enhancement of flow-mediated stimuli, which in turn upregulate the expression of eNOS, increase capillary density, and augment mitochondrial oxidative capabilitytransformations that contribute to improved resting and exercise muscle perfusion as well as metabolic efficiency (18)

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Artificial intelligence-driven integration of genetic, metabolic, and lifestyle data could facilitate dynamic, patient-specific regimens, moving beyond empirical dosing toward adaptive precision care