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Motor-coordinative and cognitive dysfunction caused by mutant TDP-43 could be reversed by inhibiting its mitochondrial localization

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The NF-B pathway represents another critical point of convergence, where selenium-containing GPx modulates NF-B to reduce inflammatory responses, while T4 suppresses NF-B nuclear translocation [75, 107]

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doi: 10.1016/j.freeradbiomed.2010.09.006 87 RianjanuA.RotoR.JulianT.HidayatS.KusumaatmajaA.SuyonoE.et al

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2 The key roles of intestinal barrier damage in gut-organ axes cross talk 2.1 Gutliver axis The gut and liver are anatomically and physiologically closely interconnected, with this intimate association originating from a shared derivation from the ventral foregut endoderm during embryogenesis (Zorn and Wells, 2009)

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In: OgwuMIzahS, editors

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-Synuclein Aggregation -Synuclein aggregation is a central pathological mechanism in PD, leading to the formation of Lewy bodies and neurodegeneration [101]

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