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In addition to its direct antitumor effects, daratumumab exerts an indirect immunomodulatory role by eliminating CD38 + immunosuppressive cell types (Treg, Breg and myeloid-derived suppressor cells) in the tumor microenvironment (TME), thereby promoting T-cell proliferation and effector functions [44]

This resistance was initially thought to be secondary to a significant decrease in surface CD38 following antibody exposure

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BPC 157 is just one example of the many peptides that have been studied for their therapeutic potential