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Ann Transl Med 7(4):71 de Vries AJ, van der Worp H, Diercks RL, van den Akker-Scheek I, Zwerver J (2015) Risk factors for patellar tendinopathy in volleyball and basketball players: a survey-based prospective cohort study

Comparing tirzepatide to semaglutide dosing Many patients arrive at tirzepatide after trying semaglutide, or they are deciding between the two

You need to dilute the powder to the desired concentration in order to reconstitute it into a usable solution

Research Use Only: The product is intended for scientific research and development purposes only

Considerations: Bioavailability may be lower compared to injections

Preclinical safety testing There are numerous references, as well as guidance documents for developing preclinical safety programs to support an FIH trial.2, 3, 4, 5 In particular, the International Conference on Harmonization (ICH) M3(R2) Nonclinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals provides recommendations of what ICH regulatory authorities expect for a safety evaluation program to enable an FIH trial.6 Additional information on requirements specific for biotechnologyderived pharmaceuticals (biologics) are provided in ICH S6(R1)7 and guidance related to nonclinical evaluation for anticancer pharmaceuticals are provided in ICH S9.8 This background of regulatory expectations is helpful to keep in mind in developing a preclinical safety testing strategy tailored for the particular needs of a drug development program (i.e., modality and indication)