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Animals were divided into groups as follows: sham-operated animals that drunk water without meldonium for four weeks before the surgical procedure (S group)

Nat Genet 2003

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Testosterone upregulates the expression of mitochondrial ND1 and ND4 and alleviates the oxidative damage to the nigrostriatal dopaminergic system in orchiectomized rats

Elongated and interconnected mitochondrial networks are typically enriched in oxidative fibers (type I and IIa), where they support sustained ATP production via OXPHOS