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Studies in vitro [70] and in vivo [71] demonstrate that NAC can suppress expression of several important neuroinflammatory molecules including matrix metalloproteinases, TNF-alpha, interleukin 1beta and inducible nitric oxide synthase in lipopolysaccharide-stimulated microglial cells and in a rat model of experimental stroke

Cardiomyopathy and cardiac arrhythmias leading to sudden death are most frequently reported [64]
Not recommended for pregnant or nursing mothers, children, or individuals sensitive to caffeine

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