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R.MukhiD.WattM.EdmundsL.XieB.CapoociJ.et al (2020)

Human umbilical vein endothelial cells (HUVEC, Lonza) were cultured in endothelial cell basal medium (EBM, Lonza) supplemented with endothelial cell growth medium (EGMSingleQuots, Lonza), 10% FBS, 2 mM L-glutamine, 100 U/mL penicillin and 100 g/mL streptomycin

found that p300 overexpression induced a modest increase in histone Kla levels, while p300 deletion decreased histone Kla levels, indicating that lactate-derived Kla is p300-dependent

Curcumin shows significant beneficial effects on human health, which include anti-inflammatory and antioxidative effects

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Together they address complementary steps in cellular metabolism