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Abstract The use of Pt(IV) complexes as pro-drugs that are activated by intracellular reduction is a widely investigated approach to overcome the limitations of Pt(II) anticancer agents

Chemico-Biol Interact 386:110788 Wenzel SE, Tyurina YY, Zhao J, St CC, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayr H, Kagan VE (2017) Pebp1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals

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And this oxidase can further generate superoxide by transferring an electron from NADPH in the cytosol to oxygen on the extracellular space, leading to increased ROS generation (59, 60)

Although the pathophysiological mechanism of the adverse effects of homoarginine deficit has not been elucidated, homoarginine supplementation has been investigated as a strategy to influence the development of cardiovascular diseases [72,73,75,76]