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MOTS-c, by contrast, is not derived from hGH at all its research relevance comes from mitochondrial retrograde signaling, a communication pathway between mitochondria and the rest of the cell that governs how energy production adapts under metabolic stress

doi: 10.1006/bbrc.2001.5232 37 GaoWSweeneyCConnollyMKennedyANgCTMcCormickJet al

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Regulation of human cystathionine beta-synthase by S-adenosyl-l-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region