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Hair is also affected by nicotine

% of iron saturation is increased
Consequently, inhibition of its small subunit xCT (SLC7A11) by the small molecule erastin results in cystine depletion and ferroptosis 29

Une production excessive peut entraner des taches sombres et l'hyperpigmentation

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Because of this, traditional linear dose reductions (for example, reducing sertraline by 50 mg increments) cause increasingly large (or hyperbolic) changes to serotonin receptor inhibition and therefore more severe symptoms
