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The British National Formulary (BNF), the British Society of Haematology Guidelines, NHS Clinical Knowledge guides, Integrated Care Board guidance notes such as this one from NHS Cambridgeshire and Peterborough, Vitamin B12 full guidance

117 Pharmacological treatment with B 12 usually implements high doses (10002000 g/day) for an average of 13 months

Vitamin B12 is a critical factor in the methylation cycle
