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FIGURE 1 2 Trimethylamine N-oxide and chronic kidney disease 2.1 Trimethylamine N-oxide is a risk factor for chronic kidney disease Risk factors for chronic kidney disease are various, including disease factors (Diabetes, hypertension, autoimmune diseases, systemic infections, urinary tract infections, acute kidney injury, etc.), Sociodemographic factors (age, gender, ethnicity, and family history of CKD, etc.), and lifestyle factor (smoking, heavy alcohol use, obesity, etc.) (Taal and Brenner, 2008

doi: 10.2165/00126839-200203040-00001

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An in vivo study further indicates that, probably due to its antioxidant effect, PQQ can reduce myocardial infarct size and improve cardiac function in rat models of ischemia [70]

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