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The surge in levels of between 50-150% of free cortisol observed at the 30 minute time point is routinely used in the scientific field to assess adrenocortical activity and the correlation of the surge in cortisol levels post awakening to chronic stress, HPA axis dysfunction, and burnout are well established (Fries et al., 2009)

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Warning signs include sweating, shakiness, dizziness, confusion, blurred vision, or feeling faint

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Further work is required to understand additional EV-derived signals that are released by adipose tissue in response to lipolysis and the mechanisms of release

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