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The meta-analysis by the Cholesterol Treatment Investigators Collaborative Group of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) and Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)showed a 21% increase in risk of hemorrhagic stroke for every 1 mmol/L reduction in LDL-C ( Other adverse effects of statins include headache, insomnia, depression, and gastrointestinal symptoms such as dyspepsia, diarrhea, abdominal pain, and nausea
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