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All these might be its modulatory effects

The supernatant was collected as the cytoplasmic fraction

Interestingly, the expression of SLC31A1 is negatively correlated with OS and tumor infiltration of plasmacytoid DCs, NK cells, and CD8 + T cells, but it is positively correlated with the high abundance of characteristic immunosuppressive immune cell types in tumors of glioma patients

Furthermore, lipid peroxidation enhances the capability of radiotherapy and chemotherapy by increasing the level of oxidative stress in cancer cells where the balance shifts toward cell death

Makkos A, Szantai A, Paloczi J, Pipis J, Kiss B, Poggi P, et al
R.SalvaneschiL.BernuzziS.et al (2010)