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The synergy between these two peptides stems from their complementary mechanisms

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The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use, (ICH)

Inhibition of the HMGB1/RAGE axis protects against cisplatin-induced ototoxicity via suppression of inflammation and oxidative stress

Ceramides help restore skin barrier function, while niacinamide can regulate oil production and reduce inflammation

Some users may experience mild side effects, such as redness or irritation at the injection site, which typically subsides on its own