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Glutathione (GSH) is the highest concentration non-protein thiol in mammalian cells and is present in concentrations of 0.5 to 10 mM

IV administration delivers the compound directly into circulation, bypassing first-pass metabolismhigher efficacy, higher risk, higher regulatory scrutiny

Here, we used terephthalic acid (TA) and 5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide (DEPMPO) to track the formation of OH in the reaction system (Supplementary Figs

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The cDNA synthesis reaction system included 10 L RNA template, 1 L RT primer (2 M), 2 L RT Mix, 2 L HiScript II Enzyme Mix, and RNase-free ddH 2 O to the final volume

On day 14, the mice were euthanized, and a histological analysis of the major organs was performed using H&E staining