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Due to the feasibility, we focused on CPs caused by mutations in epigenetic writers, which constitute the biggest group of CPs and have been most characterized in terms of immunopathology ( Figure 1 ) ( Figure 1 2 Methods 2.1 Registration This systematic review was registered in the INPLASY database (registration number: INPLASY2025120066) and is reported in accordance with PRISMA 2020 guidelines

A personalized approach is always strongly encouraged, as no two patients are the same

However, resveratrol has been reported to inhibit cell growth and induce apoptosis in normal cells at high doses, with studies showing that mice consuming large doses experienced fatal outcomes within 34 months [75,76,77,78]

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Always consult your healthcare provider if you have concerns or experience unusual symptoms

Photo-crosslinked gelatin-hyaluronic acid methacrylate hydrogel-committed nucleus pulposus-like differentiation of adipose stromal cells for intervertebral disc repair