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Additionally, to establish GSH as a reliable therapeutic option, future studies should prioritize well-designed, high-quality RCTs with standardized protocols to ensure consistency in treatment approaches and facilitate robust comparisons across different populations and ethnicities

2010 Mar;2(3):299-316

10.1016/j.jpba.2014.07.026 [DOI] [PubMed] [Google Scholar] Jordan V

Given that PGC-1 is a key regulator of mitochondrial biogenesis and an activator of antioxidant enzymes that protect mitochondria from oxidative stress, and that ferroptosis is characterized by mitochondrial alterations and phospholipid peroxidation, we hypothesized that PGC-1 may play a pivotal role in regulating ferroptosis in MASH

Available from: /pmc/articles/PMC4848680/ 56

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