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The fix: maintain at least 3 sites in rotation, ideally 5-6

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Involves needles, which some people dislike Injection site soreness or discomfort is possible Requires training or medical guidance Higher cost per dose Still lacks strong human clinical evidence NAD Nasal Spray vs Injection: Side-by-Side Comparison NAD nasal spray and NAD injections differ mainly in dose size, absorption speed, convenience, and cost

For example, Immunis Inc is developing IMM01-STEM for sarcopenic obesity 69 and Biophytis SA has progressed BIO101 (20-hydroxyecdysone) through a Phase I clinical trial 70 for age-related sarcopenia, including sarcopenic obesity