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Roughly 90 per cent of drugs that show promise in animals ultimately fail in human trials
The main limitations are GI side effects: nausea, constipation, and slowed gastric emptying
Non-PDZ scaffolding proteins: cingulin and paracingulin Cingulin and paracingulin homodimers consist of a coiled rod and globular head, which have a shared ZO-1-Interaction-Motif (ZIM) at the N-terminus
Lower baseline markers may warrant conservative initial dosing, while adequate baseline profiles may support standard protocols
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