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It was observed that Tet2 knockout mice exhibited an increase in IL-1 secretion following MSU crystal administration

Nutrients 2019

Statistical analysis was performed using GraphPad Prism 9

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Other studies have revealed signs of oxidative stress without detecting oxidative damage

Interestingly, pioglitazone exhibited neuroprotective effects in streptozotocin-induced diabetes in rats via modulation of the brain SIRT-1 signaling pathway (Tork et al