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Key trials like STEP, SURPASS, and SELECT have demonstrated their efficacy in glycemic control (HbA1c reductions of 1.02.0%) [1, 3, 4], weight loss (1020% mean body weight reduction) [2, 3, 4], and cardiovascular risk reduction [4, 7]

A mix of epidemiological, clinical, and autopsy studies demonstrated a trend of increasing lead in the blood or bones with aging, although many results were not statistically significant (Vig and Hu, 2000)

Another mechanism associated with some polyphenols is their ability to inhibit the absorption of oxidized products, such as lipid hydroxyperoxides [91]