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however, whether dietary lipids and de novo synthesized lipids are differentially metabolized remains unclear

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For the enzymatic HTML synthesis, we recombinantly produced the TMLD enzyme according to a published protocol 75

Cholelithiasis was classified as an incidental finding in 53 (86.9%) dogs, including 4 cavaliers, with 8 (13.1%) dogs being classified as symptomatic, inlcuding 2 cavaliers, having complications of cholelithiasis that included biliary duct obstruction (1 CKCS), biliary peritonitis, emphysematous cholecystitis, and acute cholecystitis (1 CKCS)

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Mouse behavioural testing Behavioural testing was conducted as described previously (Bergamasco et al, 2024)