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Furthermore, single-nucleotide polymorphisms XBP1 in patients with vitiligo illuminate the importance of this pathway in the pathogenesis of vitiligo ( 5 Nrf2 Antioxidant response pathway Oxidative stress is considered as a major event in vitiligo pathogenesis (Figure 2A)

[12] A substantial proportion (up to 45%) of people with a history of UC without any ongoing symptoms (clinical remission) have objective evidence of ongoing inflammation