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(2024) Annals of Clinical and Laboratory Science (Icahn School of Medicine at Mount Sinai), 54(2): 137148 Most recent primary research paper confirming PNC-27 binds specifically to the p53 binding site of HDM-2 (residues 1109) in the cancer cell membrane, inducing transmembrane pore formation and cancer cell necrosis
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Among the seven individuals initially diagnosed with VCD, four (57%) still exhibited the condition during the follow-up appointments, while three showed no further signs of impairment
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The observed therapeutic effect was also detected in symptomatic late-stage rodents, which opens the possibility that the compound could be effective in the advanced stages of the disease [328]

This mechanism of action is different from that of TB500 and likely works synergistically with it to create an environment that is very hostile to microbial growth
