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Another possibility involves the detoxification genes acting on odorants within the nose or, rather, not responding to odorants appropriately

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As a result, the oxidative half-reaction became rate-limiting for Y110H

Clin Ther 1991

It has been assessed that oxidative stress is associated with more than 100 diseases, including cardiovascular disease, cancer, hypertension, diabetes, neurogenerative diseases, aging, etc