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Xenobiotics usually trigger oxidative stress and may form electrophilic agents preferentially interacting with domains of DNA or proteins or lipids containing high electron density

Affinity Chromatography: Principles and Applications Sameh Magdeldin1,2 and Annette Moser3 1Department of Structural Pathology, Institute of Nephrology, Graduate School Medical and Dental Sciences, Niigata University, 2Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia,3Department of Chemistry, University of Nebraska at Kearney, Kearney, NE, 1Japan .2Egypt 3USA

These modifications can include the addition of lipid groups (lipoproteins) to anchor proteins, phosphorylation to regulate protein activity, methylation for chemotaxis, and N-acylation to integrate proteins into the lipid bilayer