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Acknowledgements This work was funded by a Children with Cancer UK fellowship (Reference 2014/178) awarded to MVNC

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1 It can take much longer for symptoms to disappear altogether, and that although their symptoms could get worse initially during treatment, this should improve 4 * Note: The large majority of patients present with neurological/neuropsychiatric involvement at the time of diagnosis References NICE Guideline on B12 deficiency in over 16s NICE Clinical Knowledge Summaries Anaemia B12 and folate deficiency Wolffenbuttel, Bruce H R et al