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There are 2 factors that might explain this phenomenon

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As Kannt & Pfenninger highlight in Frontiers in Physiology , maintaining NAD levels is a cornerstone of metabolic health, supporting mitochondrial function and improving resistance to metabolic stress (Kannt & Pfenninger, Frontiers in Physiology )

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271 Therapeutic interventions that incorporate these growth factors, either through localized delivery systems or systemic administration, could accelerate ligament healing and enhance the structural integrity of the repaired ACL