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Recent studies identify additional metabolites - including Lygodium microphyllum ( /CPT-1A pathway ( 6 Limitations of preclinical evidence and appraisal of translational gaps While current clinical management of NAFLD primarily relies on lifestyle modifications and metabolic regulation interventionsincluding insulin sensitizers, antioxidants, and lipid-lowering agentsthese approaches can delay disease progression but rarely reverse hepatic steatosis and fibrosis

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Randomization was stratified based upon current use of stimulant medication to ensure an equal distribution of stimulant/non-stimulant treated subjects into active and placebo treated groups