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(63) Chiu, Y.-H

We first showed that in the gastrocnemius muscle of the hSOD1 G93A mice, gene expression of enzymes involved in the glycolysis, TCA cycle and anaplerotic pathways such as glyceraldehyde-3-phosphate dehydrogenase, pyruvate, 2-oxoglutarate and succinate dehydrogenases, at earlier (10 weeks) and at later symptomatic stages (25 weeks) of the disease was reduced

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A Preclinical Study on the Rescue of Normal Tissue by Nicotinic Acid in High-Dose Treatment with APO866, a Specific Nicotinamide Phosphoribosyltransferase Inhibitor

doi: 10.1016/j.bpj.2013.11.049

Overall, the current approach is very efficient in the detection and structural characterization of both soft and hard reactive metabolites in a single LC-MS/MS run