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Pipecolate is further converted by pipecolic acid oxidase into piperideine-6-carboxylate (P6C), which can be spontaneously converted to AASA and enter the saccharopine pathway

10.1124/jpet.110.177287 92 ObaraI.GouldingS

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International Journal of Pharmaceutics, 658 , Article 124226

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The predicted responses of the corneal and conjunctival penetrations to the synergistic promoters are useful in controlling the extent and pathway of the ocular and systemic absorptions of instilled NAC prodrug in designed ophthalmic formulations thereof