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Among the stage 3 comparisons for the sPLS-DA component 1 proteins, we also observed that one of the top-ranking proteins was Selenoprotein P (SELENOP), one of the few GPx3 interactors detected experimentally (Fig

and standard MS3-based quantification described below

Stocchi F, Antonini A, Berg D, Bergmans B, Jost W, Katzenschlager R, et al

STK11/LKB1 inactivating mutations often cooccur with KRAS-activating mutations, and STK11/LKB1 inactivating mutations are also a driver of primary resistance to immunotherapy in KRAS-mutant lung adenocarcinoma (LUAD) (Qian et al., 2023)

The idea communicated here is that not much time was wasted in the progression from Scene 1 to Scene 2

Using a tetraphenylethene maleimide (TPE-MI) probe, we observed higher levels of free cysteine thiols in proliferating than in differentiating chondrocytes, suggesting that oxidative protein folding increases during differentiation (Extended Data Fig