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Dodge ML, Wander RC, Xia Y, Butler JA, Whanger PD

Unfortunately, the markedly increased concentration of 2-HG exceeds the sensitivity threshold for in vivo magnetic resonance spectroscopy

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The iron-rich milieu induces upregulation of the iron transporter DMT1 through two sequential mechanisms: First, unbound iron activates hypoxia-inducible factor-1 (HIF-1), which directly binds to the DMT1 promoter to enhance its transcription (Ingrassia et al

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N Engl J Med 319:223226