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All patients gave written informed consent to be treated, and the study using clinical data for research was approved by the medical ethical committee of the Slotervaart Hospital

AOD-9604 has a short half-life of approximately 30 minutes, which means each injection creates a brief window of lipolytic activity rather than sustained fat mobilization

Overexpression of NNMT has been linked to obesity, insulin resistance, and impaired NAD metabolism

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The degree of structural damage present initially may influence durability of response