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grants Pfizer-BioNTech vaccine the first emergency use authorization for a coronavirus vaccine in the United States

This design is useful for generating preliminary evidence from real clinical practice, but it has limitations compared to a randomised controlled trial (RCT)

Because several other amino acid transporters have not been studied carefully in T cells, further research is needed

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Methods In this phase 3a, double-blind, randomized, placebo-controlled trial conducted in 12 countries, we assigned adults with a body-mass index of 27 or more, a glycated hemoglobin level of 7 to 10%, and type 2 diabetes in a 3:1 ratio to receive once-weekly cagrilintide-semaglutide (2.4 mg each) or placebo, along with lifestyle intervention, for 68 weeks

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