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RBCs are particularly susceptible to oxidative stress due to the lack of nuclei needed for protein synthesis, the absence of mitochondria capable of supplying NADPH outside of the PPP, and a high iron content that drives Fenton chemistry 8

Additionally, polymorphisms in other genes involved in SFN metabolism and response have been explored

A study conducted in 2001 showed that CJC-1295 was safe and generally well tolerated in patients who received a 14-day regimen that was delivered subcutaneously

BMC Genomics 16, 19

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