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Severe congenital disabilities can occur with Accutane usage during pregnancy, including: Hearing and visual impairment Missing or malformed earlobes Brain function abnormalities Facial dysmorphisms, such as small or missing eyes or a cleft palate Congenital heart defects Hydrocephalus (fluid and pressure buildup on the brain) Any patient who can become pregnant must use two effective forms of birth control during treatment or commit to abstinence

10.7150/ntno.53888 142 PawarS.ShendeP

Epinephrine enhancement of human memory consolidation: interaction with arousal at encoding

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Pregnancy-specific Riboflavin is needed to support the increased growth and energy utilization that occurs during pregnancy

Future trials should incorporate health economic endpoints to determine whether deficiency-targeted supplementation meaningfully may enhance clinical outcomes in a cost-effective manner