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Leveraging the cartilage matrix as a drug reservoir while minimizing potential systemic toxicity holds particular significance in addressing the chronic nature of OA and its high prevalence of comorbidities

Analytical and Bioanalytical Chemistry, 380, 240246

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Wilson S, Argyropoulos S

Sub-chronic dose study in adenine-treated rats To establish hyperphosphataemia, 11-week-old normal male SD rats (CLEA Japan, Inc.) were fed a diet (CE-2, CLEA Japan Inc.) containing 0.75 % (w/w) of adenine (010-11513, FUJIFILM Wako) for 2 weeks