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In contrast, other studies have found LD buildup in astrocytes, which may interfere with their ability to neutralise aminoacyl-induced neurotoxicity in dopaminergic neurons [62]
Choi, et al
Moreover, SREBP-1C levels were significantly higher in DSS-treated mice compared to the WD and LD groups (Fig
[PMC free article: PMC2032231] [PubMed: 920777] 14
Lysosomal acid lipase, LIPA (also known as LAL) degrades lysosomal lipids, and mutations in LIPA cause accumulation of LDs in various organs 15,16 , demonstrating the importance of lipophagy for lipid homeostasis
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