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doi: 10.1007/s12178-025-09990-7

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is a membranebound enzyme that preferentially catalyzes the methylation of aliphatic sulfhydryl compounds such as captopril and Dpenicillamine, whereas is a cytoplasmic enzyme that preferentially catalyzes the methylation of aromatic and heterocyclic sulfhydryl compounds including anticancer and immunosuppressive thiopurines such as 6mercaptopurine, 6thioguanine, and azathioprine