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However, alterations of the redox balance of GSH can impair normal cellular metabolism, making cells vulnerable

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In DNCB-induced AD mouse models, systemic administration of the Vitamin D metabolite calcifediol markedly improved barrier function, evidenced by reduced transepidermal water loss, alleviation of stratum spinosum hyperplasia, and downregulation of the water-channel protein AQP3 [231]

doi: 10.1093/ons/opy283 79 HerkenhamM.LynnA

The American biochemist Loren Pickart discovered it in 1973 when he observed that liver tissue from older patients exhibited improved protein synthesis in the presence of plasma from younger donors